Current knowledge of the pre-autophagosomal structure (PAS)

被引：181

作者：

Suzuki, Kuninori ^{[1
]}

Ohsumi, Yoshinori ^{[1
]}

机构：

[1] Tokyo Inst Technol, Integrated Res Inst, Adv Res Org, Midori Ku, Yokohama, Kanagawa 2268503, Japan

来源：

FEBS LETTERS | 2010年 / 584卷 / 07期

关键词：

Autophagy; Autophagosome; Pre-autophagosomal structure; Protein degradation; Atg proteins; VACUOLE TARGETING PATHWAY; PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES; ISOLATED RAT HEPATOCYTES; ATG1 KINASE COMPLEX; SACCHAROMYCES-CEREVISIAE; SELECTIVE AUTOPHAGY; VESICLE FORMATION; ENDOPLASMIC-RETICULUM; CONJUGATION SYSTEM; PROTEIN LIPIDATION;

D O I：

10.1016/j.febslet.2010.02.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Autophagy is a system for degradation of bulk cellular components in lytic compartments, vacuoles, or lysosomes when eukaryotic cells face with nutrient starvation. In this review, we focus on the pre-autophagosomal structure (PAS), a functional entity responsible for autophagosome formation in Saccharomyces cerevisiae, and discuss its relevance to autophagy in mammalian cells. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

收藏

页码：1280 / 1286

页数：7

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