Improved synthesis of dihydrothebainone and its 14β-epimer

被引：5

作者：

Davidson, MR ^{[1
]}

Gregg, BT ^{[1
]}

机构：

[1] Albany Mol Res Inc, Dept Med Chem, Albany, NY 12203 USA

来源：

SYNTHETIC COMMUNICATIONS | 1998年 / 28卷 / 03期

关键词：

D O I：

10.1080/00397919808005110

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved synthesis for the preparation of diastereomerically pure dihydrothebainone (1) from thebaine (3) is reported. A 41% overall yield was realized over three steps via direct transformation of dihydrothebaine-Phi (4) to thebainone-A (6) with 6N HCl.

引用

页码：547 / 558

页数：12

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