Molecular insights into cardiac development

被引：56

作者：

Sucov, HM ^{[1
]}

机构：

[1] Univ So Calif, Sch Med, Inst Med Genet, Dept Cell Neurobiol, Los Angeles, CA 90033 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 1998年 / 60卷

关键词：

cardiogenesis; cardiac morphogenesis;

D O I：

10.1146/annurev.physiol.60.1.287

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Recent discoveries have led to a greater appreciation of the diverse mechanisms that underlie cardiac morphogenesis. Genetic strategies (primarily gene targeting approaches in mice) have significantly broadened research in cardiovascular developmental biology by illuminating new pathways involved in heart development and by allowing the genetic evaluation of pathways that have previously been implicated in these events. Advances have also been made using biochemical and cell-and tissue-based approaches. This review summarizes the author's interpretation of current trends in the effort to understand the molecular basis of cardiac development, with an emphasis on insights obtained from genetic models.

引用

页码：287 / 308

页数：22

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