Virus-like particles as vaccines and vessels for the delivery of small molecules

被引：168

作者：

Garcea, RL ^{[1
]}

Gissmann, L

机构：

[1] Univ Colorado, Sch Med, Sect Pediat Hematol Oncol, Denver, CO 80262 USA

[2] Deutsch Krebsforschungszentrum, FS Infekt & Krebs, D-69120 Heidelberg, Germany

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2004年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.copbio.2004.10.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Virus-like particles (VLPs) structurally mimic the viral capsid and have therefore been extensively, and quite successfully, used as vaccine and viral serology reagents. The ability of VLPs to include nucleic acids and small molecules has also made them novel vessels for gene and drug delivery. The regular, repetitive surface of VLPs has been exploited as a template for nanoscale synthesis. Recent progress has been made in the development of several virus models.

引用

页码：513 / 517

页数：5

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