Comparison of posterior fossa and tumor bed boost in medulloblastoma

被引:8
作者
Paulino, AC [1 ]
Saw, CB [1 ]
Wen, BC [1 ]
机构
[1] Univ Iowa, Coll Med, Dept Radiol, Div Radiat Oncol, Iowa City, IA 52242 USA
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 2000年 / 23卷 / 05期
关键词
medulloblastoma; posterior fossa boost; tumor bed boost; cochlea; radiotherapy;
D O I
10.1097/00000421-200010000-00011
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To quantify the difference between the area of brain irradiated using the posterior fossa boost (PFB) and tumor bed boost (TBB) in medulloblastoma, we studied 15 simulation radiographs of patients treated in our institution from 1990 and 1999. The PFB was compared with the TBB, which was defined as the tumor bed plus 2-cm margin as demonstrated by postoperative magnetic resonance imaging. The PFB field treated a mean area of 9.43 cm(2) more brain than the TBB. In 3 patients (20%), the area of the brain in the TBB was larger than the PFB. In 11 patients (73.3%), the PFB field had more than 10% more brain than the TBB. The cochlea was in the PFB and TBB field in all patients. In more than two thirds of patients, the area of brain irradiated with the PFB was at least 10% greater than the TBB. Future studies are needed to determine whether the TBB can replace the PFB in patients with medulloblastoma.
引用
收藏
页码:487 / 490
页数:4
相关论文
共 14 条
[1]  
Ayan I, 1997, INT J RADIAT ONCOL, V39, P461
[2]   QUALITY-CONTROL OF RADIOTHERAPEUTIC TREATMENT OF MEDULLOBLASTOMA IN A MULTICENTRIC STUDY - THE CONTRIBUTION OF RADIOTHERAPY TECHNIQUE TO TUMOR RELAPSE [J].
CARRIE, C ;
ALAPETITE, C ;
MERE, P ;
AIMARD, L ;
PONS, A ;
KOLODIE, H ;
SENG, S ;
LAGRANGE, JL ;
PONTVERT, D ;
PIGNON, T ;
LACROZE, M ;
GINESTET, C ;
BERNARD, JL .
RADIOTHERAPY AND ONCOLOGY, 1992, 24 (02) :77-81
[3]   AN OPERATIVE STAGING SYSTEM AND A MEGAVOLTAGE RADIOTHERAPEUTIC TECHNIC FOR CEREBELLAR MEDULLOBLASTOMAS [J].
CHANG, CH ;
HOUSEPIAN, EM ;
HERBERT, C .
RADIOLOGY, 1969, 93 (06) :1351-+
[4]   The use of 3D conformal radiotherapy (3D CRT) to spare the cochlea in patients with medulloblastoma [J].
Fukunaga-Johnson, N ;
Sandler, HM ;
Marsh, R ;
Martel, MK .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 41 (01) :77-82
[5]   Patterns of failure following treatment for medulloblastoma: Is it necessary to treat the entire posterior fossa? [J].
Fukunaga-Johnson, N ;
Lee, JH ;
Sandler, HM ;
Robertson, P ;
McNeil, E ;
Goldwein, JW .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 42 (01) :143-146
[6]  
HUGHES ENH, 1988, CANCER, V61, P1991
[7]   Treatment results for 149 medulloblastoma patients from one institution [J].
Khafaga, Y ;
Kandil, AE ;
Jamshed, A ;
Hassounah, M ;
DeVol, E ;
Gray, AJ .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1996, 35 (03) :501-506
[8]   Medulloblastoma: Long-term results for patients treated with definitive radiation therapy during the computed tomography era [J].
Merchant, TE ;
Wang, MH ;
Haida, T ;
Lindsley, KL ;
Finlay, J ;
Dunkel, IJ ;
Rosenblum, MK ;
Leibel, SA .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1996, 36 (01) :29-35
[9]   Pediatric medulloblastoma: Radiation treatment technique and patterns of failure [J].
Miralbell, R ;
Bleher, A ;
Huguenin, P ;
Ries, G ;
Kann, R ;
Mirimanoff, RO ;
Notter, M ;
Nouet, P ;
Bieri, S ;
Thum, P ;
Toussi, H .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 37 (03) :523-529
[10]  
Paulino AC, 1999, CANCER, V86, P142, DOI 10.1002/(SICI)1097-0142(19990701)86:1<142::AID-CNCR20>3.0.CO