Chemokines mediate mesenchymal stem cell migration toward gliomas in vitro

被引：83

作者：

Xu, Feng ^{[1
]}

Shi, Jinlong ^{[2
]}

Yu, Bin ^{[3
]}

Ni, Wei ^{[1
]}

Wu, Xing ^{[1
]}

Gu, Zhikai ^{[2
]}

机构：

[1] Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai Neurosurg Ctr, Shanghai 200040, Peoples R China

[2] Nantong Univ, Affiliated Hosp, Dept Neurosurg, Nantong 226001, Jiangsu, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Canc Inst, WHO Collaborating Ctr Res Canc, Natl Lab Oncogenes & Related Genes, Shanghai 200032, Peoples R China

来源：

ONCOLOGY REPORTS | 2010年 / 23卷 / 06期

关键词：

macrophage chemoattractant protein-1; stromal cell-derived factor-1 alpha; mesenchymal stem cells; migration; glioma; MONOCYTE CHEMOATTRACTANT PROTEIN-1; MARROW STROMAL CELLS; NEURONAL PROGENITOR CELLS; BONE-MARROW; GENE-THERAPY; MALIGNANT GLIOMAS; BRAIN-TUMORS; MACROPHAGE INFILTRATION; INTRACRANIAL GLIOMA; HUMAN GLIOBLASTOMA;

D O I：

10.3892/or_00000796

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous studies have demonstrated the tremendous tropism of mesenchymal stem cells (MSCs) for malignant gliomas, making these cells a potential vehicle for delivery of therapeutic genes to disseminated glioma cells. However, the mechanisms underlying the tropism of MSCs for gliomas remain poorly defined. It has been suggested that malignant gliomas secrete a variety of chemokines, including macrophage chemoattractant protein-1 (MCP-1) and stromal cell-derived factor-1 alpha (SDF-1 alpha). We isolated and cultured MSCs from rat bone marrow and found that these cells express CCR2 and CXCR4, the respective receptors for MCP-1 and SDF-1 alpha. In vitro analysis revealed that MCP-1 and SDF-1 alpha induce the migration of MSCs. Futhermore, neutralization data suggest that MCP-1 and SDF-1 alpha play a role in the mediation of MSC migration toward gliomas. These results highlight the potential of these cells as a tumor targeting strategy for glioma gene therapy.

引用

页码：1561 / 1567

页数：7

共 48 条

[1] Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas [J].

Aboody, KS ;

Brown, A ;

Rainov, NG ;

Bower, KA ;

Liu, SX ;

Yang, W ;

Small, JE ;

Herrlinger, U ;

Ourednik, V ;

Black, PM ;

Breakefield, XO ;

Snyder, EY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12846-12851

[2] Murine neuronal progenitor cells are preferentially recruited to tumor vasculature via α4-integrin and SDF-1α-dependent mechanisms [J].

Allport, JR ;

Patil, VRS ;

Weissleder, R .

CANCER BIOLOGY & THERAPY, 2004, 3 (09) :838-844

[3]

Barbero S, 2003, CANCER RES, V63, P1969

[4] Gene therapy of experimental brain tumors using neural progenitor cells [J].

Benedetti, S ;

Pirola, B ;

Pollo, B ;

Magrassi, L ;

Bruzzone, MG ;

Rigamonti, D ;

Galli, R ;

Selleri, S ;

Di Meco, F ;

De Fraja, C ;

Vescovi, A ;

Cattaneo, E ;

Finocchiaro, G .

NATURE MEDICINE, 2000, 6 (04) :447-450

[5] Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines [J].

Birnbaum, Tobias ;

Roider, Julia ;

Schankin, Christoph J. ;

Padovan, Claudio S. ;

Schichor, Christian ;

Goldbrunner, Roland ;

Straube, Andreas .

JOURNAL OF NEURO-ONCOLOGY, 2007, 83 (03) :241-247

[6] Intravascular delivery of neural stem cell lines to target intracranial and extracranial tumors of neural and non-neural origin [J].

Brown, AB ;

Yang, W ;

Schmidt, NO ;

Carroll, R ;

Leishear, KK ;

Rainov, NG ;

Black, PM ;

Breakefield, XO ;

Aboody, KS .

HUMAN GENE THERAPY, 2003, 14 (18) :1777-1785

[7] Medical progress: Brain tumors [J].

DeAngelis, LM .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (02) :114-123

[8] HUMAN ASTROCYTOMAS AND GLIOBLASTOMAS EXPRESS MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) IN-VIVO AND IN-VITRO [J].

DESBAILLETS, I ;

TADA, M ;

DETRIBOLET, N ;

DISERENS, AC ;

HAMOU, MF ;

VAN MEIR, EG .

INTERNATIONAL JOURNAL OF CANCER, 1994, 58 (02) :240-247

[9] The neurosurgeon as local oncologist: Cellular and molecular neurosurgery in malignant glioma therapy [J].

Dunn, IF ;

Black, PM .

NEUROSURGERY, 2003, 52 (06) :1411-1422

[10] Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells [J].

Dwyer, R. M. ;

Potter-Beirne, S. M. ;

Harrington, K. A. ;

Lowery, A. J. ;

Hennessy, E. ;

Murphy, J. M. ;

Barry, F. P. ;

O'Brien, T. ;

Kerin, M. J. .

CLINICAL CANCER RESEARCH, 2007, 13 (17) :5020-5027

← 1 2 3 4 5 →