Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice

被引：159

作者：

van Es, T. ^{[1
]}

van Puijvelde, G. H. M. ^{[1
]}

Ramos, O. H. ^{[1
]}

Segers, F. M. E. ^{[1
]}

Joosten, L. A. ^{[2
]}

van den Berg, W. B. ^{[2
]}

Michon, I. M. ^{[1
]}

de Vos, P. ^{[1
]}

van Berkel, Th. J. C. ^{[1
]}

Kuiper, J. ^{[1
]}

机构：

[1] Leiden Univ, Div Biopharmaceut, LACDR, NL-2300 RA Leiden, Netherlands

[2] Radboud Univ Nijmegen, Nijmegen Med Ctr, NL-6525 ED Nijmegen, Netherlands

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 388卷 / 02期

关键词：

Atherosclerosis; LDL receptor deficient mice; Interleukin-17; Bone marrow transplantation; SMOOTH-MUSCLE-CELLS; MAST-CELLS; T-CELLS; AUTOIMMUNE INFLAMMATION; INTERLEUKIN-17; FAMILY; RECEPTOR; EXPRESSION; CYTOKINE; CHEMOKINE; RECRUITMENT;

D O I：

10.1016/j.bbrc.2009.07.152

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Atherosclerosis is an inflammatory disease characterized by the influx of macrophages and T cells and IL-17 may connect innate and adaptive immune responses involved in atherogenesis. We investigated the role of IL-17 receptor signaling in atherosclerosis and transplanted LDLr deficient recipient mice with IL-17R deficient bone marrow. Induction of atherosclerosis by Western-type diet induced a 46% reduction in lesion size in the aortic root and the plaque composition revealed no significant changes in collagen content and neutrophil counts, but a reduction in mast cell number and an increase in macrophage number. In addition, we observed a decrease in anti-oxLDL antibodies of the IgG class upon IL-17R BMT, while introduction of IL-17R deficient bone marrow resulted in a reduced IL-6 production and an increased IL-10 production. In conclusion, signaling via the IL-17 receptor in bone marrow derived cells enhances the process of atherosclerosis. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：261 / 265

页数：5

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