Stereocomplex block copolymer micelles:: Core-shell nanostructures with enhanced stability

被引：298

作者：

Kang, N

Perron, MÉ

Prud'homme, RE

Zhang, YB

Gaucher, G

Leroux, JC

机构：

[1] Univ Montreal, Canada Res Chair Drug Delivery, Fac Pharm, Montreal, PQ H3C 3J7, Canada

[2] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

来源：

NANO LETTERS | 2005年 / 5卷 / 02期

关键词：

D O I：

10.1021/nl048037v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monodisperse stereocomplex block copolymer micelles were obtained through the self-assembly of equimolar mixtures of poly(ethylene glycol)block-poly(L-lactide) and poly(ethylene glycol)-block-poly(D-lactide) in water. These micelles possessed partially crystallized cores and mean hydrodynamic diameters ranging from 31 to 56 nm, depending on the lactide content. They exhibited kinetic stability and redispersion properties superior to micelles prepared with isotactic or racemic polymers alone. This study demonstrates the advantages of stereocomplex formation in the design of stabilized water-soluble nanoparticles.

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页码：315 / 319

页数：5

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