Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

被引：87

作者：

Lamine, Aurelia ^{[1
]}

Caumont-Sarcos, Anne

Chaix, Marie-Laure

Saez-Cirion, Asier

Rouzioux, Christine

Delfraissy, Jean-Francois

Pancino, Gianfranco

Lambotte, Olivier

机构：

[1] Univ Paris 11, INSERM, U802, Le Kremlin Bicetre, France

[2] Univ Bordeaux 2, CNRS, UMR 5097 Lab, F-33076 Bordeaux, France

[3] CHU Necker, Virol Lab, EA MRT, F-75015 Paris, France

[4] Inst Pasteur, Regulat Retroviral Infect Unit, Paris, France

[5] Hop Bicetre, Dept Internal Med & Infect Dis, Le Kremlin Bicetre, France

来源：

AIDS | 2007年 / 21卷 / 08期

关键词：

D O I：

10.1097/QAD.0b013e3280d5a7ac

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The replicative potential of HIV-1 strains in a well-characterized group of eight HIV controllers was investigated. Replication-competent viruses were detected in CD4 T-cell co-culture supernatants from all HIV controllers. The phylogenetic analysis of C2V4 suggested viral evolution or co-infection or superinfection in two out of the four patients analysed. The vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers.

引用

页码：1043 / 1045

页数：3

共 18 条

[1] Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations [J].

Bailey, Justin R. ;

Williams, Thomas M. ;

Siliciano, Robert F. ;

Blankson, Joel N. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (05) :1357-1369

[2]

Candotti D, 1999, J MED VIROL, V58, P256, DOI 10.1002/(SICI)1096-9071(199907)58:3&lt

[3]

256::AID-JMV11&gt

[4]

3.0.CO

[5]

2-Z

[6] VIROLOGICAL AND IMMUNOLOGICAL CHARACTERIZATION OF LONG-TERM SURVIVORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].

CAO, YZ ;

QIN, LM ;

ZHANG, LQ ;

SAFRIT, J ;

HO, DD .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (04) :201-208

[7] Longitudinal analysis of human immunodeficiency virus type 1 nef/long terminal repeat sequences in a cohort of long-term survivors infected from a single source [J].

Churchill, MJ ;

Rhodes, DI ;

Learmont, JC ;

Sullivan, JS ;

Wesselingh, SL ;

Cooke, IRC ;

Deacon, NJ ;

Gorry, PR .

JOURNAL OF VIROLOGY, 2006, 80 (02) :1047-1052

[8] Nef Alleles from human immunodeficiency virus type 1-infected long-term-nonprogressor hemophiliacs with or without late disease progression are defective in enhancing virus replication and CD4 down-regulation [J].

Crotti, Andrea ;

Neri, Francesca ;

Corti, Davide ;

Ghezzi, Silvia ;

Heltai, Silvia ;

Baur, Andreas ;

Poli, Guido ;

Santagostino, Elena ;

Vicenzi, Elisa .

JOURNAL OF VIROLOGY, 2006, 80 (21) :10663-10674

[9] Natural controlled HIV infection: Preserved HIV-specific immunity despite undetectable replication competent virus [J].

Kloosterboer, N ;

Groeneveld, PHP ;

Jansen, CA ;

van der Vorst, TJK ;

Koning, F ;

Winkel, CN ;

Duits, AJ ;

Miedema, F ;

van Baarle, D ;

van Rij, RP ;

Brinkman, K ;

Schuitemaker, H .

VIROLOGY, 2005, 339 (01) :70-80

[10] The lymphocyte HIV reservoir in patients on long-term HAART is a memory of virus evolution [J].

Lambotte, O ;

Chaix, ML ;

Gubler, B ;

Nasreddine, N ;

Wallon, C ;

Goujard, C ;

Rouzioux, C ;

Taoufik, Y ;

Delfraissy, JF .

AIDS, 2004, 18 (08) :1147-1158

← 1 2 →