CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA

被引：46

作者：

Bracci-Laudiero, L

Celestino, D

Starace, G

Antonelli, A

Lambiase, A

Procoli, A

Rumi, C

Lai, M

Picardi, A

Ballatore, G

Bonini, S

Aloe, L

机构：

[1] CNR, Inst Neurobiol & Mol Med, I-00137 Rome, Italy

[2] Univ Roma La Sapienza, Dept Med Therapy, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Dept Hematol, I-00168 Rome, Italy

[4] Univ Roma Tor Vergata, St Eugenio Hosp, Dept Haematol, Rome, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 136卷 / 1-2期

关键词：

human stem cells; neurotrophins; hematopoiesis;

D O I：

10.1016/S0165-5728(03)00007-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34(+) cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34(+) cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：130 / 139

页数：10

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