Sliding doors: clathrin-coated pits or caveolae?

被引：24

作者：

Felberbaum-Corti, M ^{[1
]}

Van der Goot, FG ^{[1
]}

Gruenberg, J ^{[1
]}

机构：

[1] CMU, Dept Genet & Microbiol, CH-1211 Geneva 4, Switzerland

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 05期

关键词：

D O I：

10.1038/ncb0503-382

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Some cell-surface receptors activate downstream signal transduction pathways not only from the cell surface but also from endosomes, suggesting that signalling pathways can be regulated by compartmentalization. A further twist is that different internalization routes seem to predetermine whether transforming growth factor beta (TGF-beta) receptors will trigger a signalling response or be degraded.

引用

页码：382 / 384

页数：3

共 16 条

[1] Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process [J].

Abrami, L ;

Liu, SH ;

Cosson, P ;

Leppla, SH ;

van der Goot, FG .

JOURNAL OF CELL BIOLOGY, 2003, 160 (03) :321-328

[2] Signal transduction by the TGF-β superfamily [J].

Attisano, L ;

Wrana, JL .

SCIENCE, 2002, 296 (5573) :1646-1647

[3] Regulated portals of entry into the cell [J].

Conner, SD ;

Schmid, SL .

NATURE, 2003, 422 (6927) :37-44

[4] Distinct endocytic pathways regulate TGF-β receptor signalling and turnover [J].

Di Guglielmo, GM ;

Le Roy, C ;

Goodfellow, AF ;

Wrana, JL .

NATURE CELL BIOLOGY, 2003, 5 (05) :410-421

[5] Signaling from the far side [J].

Felberbaum-Corti, M ;

Gruenberg, J .

MOLECULAR CELL, 2002, 10 (06) :1259-1260

[6] The endocytic pathway: A mosaic of domains [J].

Gruenberg, J .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (10) :721-730

[7] TGFβ receptor internalization into EEA1-enriched early endosomes:: role in signaling to Smad2 [J].

Hayes, S ;

Chawla, A ;

Corvera, S .

JOURNAL OF CELL BIOLOGY, 2002, 158 (07) :1239-1249

[8] Clathrin-dependent or not: Is it still the question? [J].

Johannes, L ;

Lamaze, C .

TRAFFIC, 2002, 3 (07) :443-451

[9] Receptor downregulation and multivesicular-body sorting [J].

Katzmann, DJ ;

Odorizzi, G ;

Emr, SD .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (12) :893-905

[10] Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFβ receptor for degradation [J].

Kavsak, P ;

Rasmussen, RK ;

Causing, CG ;

Bonni, S ;

Zhu, HT ;

Thomsen, GH ;

Wrana, JL .

MOLECULAR CELL, 2000, 6 (06) :1365-1375

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