Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy

被引：27

作者：

Shamim, Z. ^{[1
]}

Muller, K.

Svejgaard, A.

Poulsen, L. K.

Bodtger, U.

Ryder, L. P.

机构：

[1] Rigshosp, Dept 7551, Paediat Clin 2, Copenhagen, Denmark

[2] Rigshosp, Dept 7551, Allergy Clin, Copenhagen, Denmark

来源：

INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2007年 / 34卷 / 03期

关键词：

D O I：

10.1111/j.1744-313X.2007.00657.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7R alpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7R alpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

引用

页码：149 / 151

页数：3

共 25 条

[1] DEFECTIVE LYMPHOID DEVELOPMENT IN MICE LACKING EXPRESSION OF THE COMMON CYTOKINE RECEPTOR-GAMMA CHAIN [J].

CAO, XQ ;

SHORES, EW ;

HULI, J ;

ANVER, MR ;

KELSALL, BL ;

RUSSELL, SM ;

DRAGO, J ;

NOGUCHI, M ;

GRINBERG, A ;

BLOOM, ET ;

PAUL, WE ;

KATZ, SI ;

LOVE, PE ;

LEONARD, WJ .

IMMUNITY, 1995, 2 (03) :223-238

[2] LYMPHOID DEVELOPMENT IN MICE WITH A TARGETED DELETION OF THE INTERLEUKIN-2 RECEPTOR-GAMMA CHAIN [J].

DISANTO, JP ;

MULLER, W ;

GUYGRAND, D ;

FISCHER, A ;

RAJEWSKY, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (02) :377-381

[3] POSITION PAPER - ALLERGEN STANDARDIZATION AND SKIN-TESTS [J].

DREBORG, S ;

FREW, A .

ALLERGY, 1993, 48 (14) :49-82

[4]

FREEMAN HL, 1995, J DRUG DEV CLIN PR, V7, P7

[5]

FRY H, 2002, TEACH HIGH EDUC, V7, P99

[6] INHIBITION OF MURINE B-LYMPHOPOIESIS AND T-LYMPHOPOIESIS INVIVO BY AN ANTI-INTERLEUKIN-7 MONOCLONAL-ANTIBODY [J].

GRABSTEIN, KH ;

WALDSCHMIDT, TJ ;

FINKELMAN, FD ;

HESS, BW ;

ALPERT, AR ;

BOIANI, NE ;

NAMEN, AE ;

MORRISSEY, PJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (01) :257-264

[7] The structure and function of γc-dependent cytokines and receptors:: Regulation of T lymphocyte development and homeostasis [J].

He, YW ;

Malek, TR .

CRITICAL REVIEWS IN IMMUNOLOGY, 1998, 18 (06) :503-524

[8]

Kim K, 1998, J IMMUNOL, V160, P5735

[9] Shared gamma(c) subunit within the human interleukin-7 receptor complex - A molecular basis for the pathogenesis of X-linked severe combined immunodeficiency [J].

Lai, SY ;

Molden, J ;

Goldsmith, MA .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (02) :169-177

[10] TSLP: finally in the limelight [J].

Leonard, WJ .

NATURE IMMUNOLOGY, 2002, 3 (07) :605-607

← 1 2 3 →