Syntheses and evaluation of benzodiazaborine compounds against M-tuberculosis H37RV in vitro

被引：51

作者：

Davis, MC

Franzblau, SG

Martin, AR ^{[1
]}

机构：

[1] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA

[2] Louisiana State Univ, GWL Hansens Dis Ctr, Baton Rouge, LA 70894 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(98)00126-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of six benzo[e]diazaborine compounds and thier in vitro evaluation against M. tuberculosis H37Rv is described. The compounds 1,2-dihydro-1-hydroxy-2-phenyl-2,4,1 -benzo[e]diazaborin-3 (4H)-one, 4, and 1,2-dihydro-1-hydroxy-2-(3-pyridyl)-2,4,1-benzo[e]diazaborin-3(4H)-thione, (5), showed the greatest inhibitory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：843 / 846

页数：4

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