PHD2 in tumour angiogenesis

被引：69

作者：

Chan, D. A. ^{[2
]}

Giaccia, A. J. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Radiat Oncol, Stanford, CA 94305 USA

[2] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA 94143 USA

来源：

BRITISH JOURNAL OF CANCER | 2010年 / 103卷 / 01期

关键词：

PHD2; tumour angiogenesis; HIF; HYPOXIA-INDUCIBLE-FACTOR; HYDROXYLASE DOMAIN PROTEIN-2; HIF-ALPHA; TRANSCRIPTIONAL ACTIVITY; PROLINE HYDROXYLATION; CELL-PROLIFERATION; RENAL-CARCINOMA; HIF-1-ALPHA; VHL; CANCER;

D O I：

10.1038/sj.bjc.6605682

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Originally identified as the enzymes responsible for catalysing the oxidation of specific, conserved proline residues within hypoxia-inducible factor-1 alpha (HIF-1 alpha), the additional roles for the prolyl hydroxylase domain (PHD) proteins have remained elusive. Of the four identified PHD enzymes, PHD2 is considered to be the key oxygen sensor, as knockdown of PHD2 results in elevated HIF protein. Several recent studies have highlighted the importance of PHD2 in tumourigenesis. However, there is conflicting evidence as to the exact role of PHD2 in tumour angiogenesis. The divergence seems to be because of the contribution of stromal-derived PHD2, and in particular the involvement of endothelial cells, vs tumour-derived PHD2. This review summarises our current understanding of PHD2 and tumour angiogenesis, focusing on the influences of PHD2 on vascular normalisation and neovascularisation. British Journal of Cancer (2010) 103, 1-5. doi:10.1038/sj.bjc.6605682 www.bjcancer.com Published online 11 May 2010 (C) 2010 Cancer Research UK

引用

页码：1 / 5

页数：5

共 41 条

[1]

Genetic evidence for a tumor suppressor role of HIF-2α [J].

Acker, T ;

Diez-Juan, A ;

Aragones, J ;

Tjwa, M ;

Brusselmans, K ;

Moons, L ;

Fukumura, D ;

Moreno-Murciano, MP ;

Herbert, JM ;

Burger, A ;

Riedel, J ;

Elverl, G ;

Flamme, I ;

Maxwell, PH ;

Collen, D ;

Dewerchin, M ;

Jain, RK ;

Plate, KH ;

Carmeliet, P .

CANCER CELL, 2005, 8 (02) :131-141

[2]

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism [J].

Aragones, Julian ;

Schneider, Martin ;

Van Geyte, Katie ;

Fraisl, Peter ;

Dresselaers, Tom ;

Mazzone, Massimiliano ;

Dirkx, Ruud ;

Zacchigna, Serena ;

Lemieux, Helene ;

Jeoung, Nam Ho ;

Lambrechts, Diether ;

Bishop, Tammie ;

Lafuste, Peggy ;

Diez-Juan, Antonio ;

Harten, Sarah K. ;

Van Noten, Pieter ;

De Bock, Katrien ;

Willam, Carsten ;

Tjwa, Marc ;

Grosfeld, Alexandra ;

Navet, Rachel ;

Moons, Lieve ;

Vandendriessche, Thierry ;

Deroose, Christophe ;

Wijeyekoon, Bhathiya ;

Nuyts, Johan ;

Jordan, Benedicte ;

Silasi-Mansat, Robert ;

Lupu, Florea ;

Dewerchin, Mieke ;

Pugh, Chris ;

Salmon, Phil ;

Mortelmans, Luc ;

Gallez, Bernard ;

Gorus, Frans ;

Buyse, Johan ;

Sluse, Francis ;

Harris, Robert A. ;

Gnaiger, Erich ;

Hespel, Peter ;

Van Hecke, Paul ;

Schuit, Frans ;

Van Veldhoven, Paul ;

Ratcliffe, Peter ;

Baes, Myriam ;

Maxwell, Patrick ;

Carmeliet, Peter .

NATURE GENETICS, 2008, 40 (02) :170-180

[3]

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia [J].

Berra, E ;

Benizri, E ;

Ginouvès, A ;

Volmat, V ;

Roux, D ;

Pouysségur, J .

EMBO JOURNAL, 2003, 22 (16) :4082-4090

[4]

Role of HIF-1α or in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis [J].

Carmeliet, P ;

Dor, Y ;

Herbert, JM ;

Fukumura, D ;

Brusselmans, K ;

Dewerchin, M ;

Neeman, M ;

Bono, F ;

Abramovitch, R ;

Maxwell, P ;

Koch, CJ ;

Ratcliffe, P ;

Moons, L ;

Jain, RK ;

Collen, D ;

Keshet, E .

NATURE, 1998, 394 (6692) :485-490

[5]

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment [J].

Chan, Denise A. ;

Kawahara, Tiara L. A. ;

Sutphin, Patrick D. ;

Chang, Howard Y. ;

Chi, Jen-Tsan ;

Giaccia, Amato J. .

CANCER CELL, 2009, 15 (06) :527-538

[6]

Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity [J].

Cummins, Eoin P. ;

Berra, Edurne ;

Comerford, Katrina M. ;

Ginouves, Amandine ;

Fitzgerald, Kathleen T. ;

Seeballuck, Fergal ;

Godson, Catherine ;

Nielsen, Jens E. ;

Moynagh, Paul ;

Pouyssegur, Jacques ;

Taylor, Cormac T. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (48) :18154-18159

[7]

Hypoxia-inducible factor-1α promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts [J].

Dang, DT ;

Chen, F ;

Gardner, LB ;

Cummins, JM ;

Rago, C ;

Bunz, F ;

Kantsevoy, SV ;

Dang, LH .

CANCER RESEARCH, 2006, 66 (03) :1684-1693

[8]

HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion [J].

Du, Rose ;

Lu, Kan V. ;

Petritsch, Claudia ;

Liu, Patty ;

Ganss, Ruth ;

Passegue, Emmanuelle ;

Song, Hanqiu ;

VandenBerg, Scott ;

Johnson, Randall S. ;

Werb, Zena ;

Bergers, Gabriele .

CANCER CELL, 2008, 13 (03) :206-220

[9]

Erez N, 2003, CANCER RES, V63, P8777

[10]

GNARRA JR, 1993, UROL CLIN N AM, V20, P207

← 1 2 3 4 5 →