Involvement of nitric oxide synthase in proteinuria associated with chronic renal disease in rats

被引：5

作者：

Brooks, DP ^{[1
]}

Contino, LC ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Dept Renal Pharmacol, King Of Prussia, PA 19406 USA

来源：

PHARMACOLOGY | 1998年 / 56卷 / 05期

关键词：

D O I：

10.1159/000028206

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study demonstrates that the nitric oxide synthase inhibitor, aminoguanidine, can attenuate the proteinuria observed in a predominantly noninflammatory model of chronic renal disease in the rat. These data suggest that nitric oxide synthase may be involved in progressive renal disease.

引用

页码：257 / 261

页数：5

共 15 条

[1] THERAPEUTIC ADVANTAGE OF CONVERTING ENZYME-INHIBITORS IN ARRESTING PROGRESSIVE RENAL-DISEASE ASSOCIATED WITH SYSTEMIC HYPERTENSION IN THE RAT [J].

ANDERSON, S ;

RENNKE, HG ;

BRENNER, BM .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (06) :1993-2000

[2] COMPARISON BETWEEN CARVEDILOL AND CAPTOPRIL IN RATS WITH PARTIAL ABLATION-INDUCED CHRONIC-RENAL-FAILURE [J].

BROOKS, DP ;

SHORT, BG ;

CYRONAK, MJ ;

CONTINO, LC ;

DICRISTO, M ;

WANG, YX ;

RUFFOLO, RR .

BRITISH JOURNAL OF PHARMACOLOGY, 1993, 109 (02) :581-586

[3]

BROOKS DP, 1995, J PHARMACOL EXP THER, V274, P122

[4]

CATTELL V, 1993, EXP NEPHROL, V1, P265

[5]

COOK HT, 1994, CLIN EXP IMMUNOL, V97, P315

[6] AMINOGUANIDINE, A NOVEL INHIBITOR OF NITRIC-OXIDE FORMATION, PREVENTS DIABETIC VASCULAR DYSFUNCTION [J].

CORBETT, JA ;

TILTON, RG ;

CHANG, K ;

HASAN, KS ;

IDO, Y ;

WANG, JL ;

SWEETLAND, MA ;

LANCASTER, JR ;

WILLIAMSON, JR ;

MCDANIEL, ML .

DIABETES, 1992, 41 (04) :552-556

[7]

DAVIDSOHN L, 1969, CLIN DIAGNOSIS LAB M, P48

[8] NITRIC-OXIDE - A CYTO-TOXIC ACTIVATED MACROPHAGE EFFECTOR MOLECULE [J].

HIBBS, JB ;

TAINTOR, RR ;

VAVRIN, Z ;

RACHLIN, EM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (01) :87-94

[9]

KOHAN D E, 1992, Journal of the American Society of Nephrology, V3, P546

[10] ANGIOTENSIN-II RECEPTOR BLOCKADE LIMITS GLOMERULAR INJURY IN RATS WITH REDUCED RENAL MASS [J].

LAFAYETTE, RA ;

MAYER, G ;

PARK, SK ;

MEYER, TW .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (03) :766-771

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