Age-related Defects in Sensorimotor Activity, Spatial Learning, and Memory in C57BL/6 Mice

被引：62

作者：

Barreto, George ^{[1
]}

Huang, Ting-Ting ^{[2
]}

Giffard, Rona G. ^{[1
]}

机构：

[1] Stanford Univ, Dept Anesthesia, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

来源：

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY | 2010年 / 22卷 / 03期

基金：

美国国家卫生研究院;

关键词：

C57BL/6; mice; postoperative cognitive dysfunction; aging; behavior; sensorimotor; spatial learning; memory; FOCAL CEREBRAL-ISCHEMIA; BARNES MAZE; RATS; BRAIN; DYSFUNCTION; BEHAVIOR; DEFICITS; MOUSE; CONSEQUENCES; IMPAIRMENT;

D O I：

10.1097/ANA.0b013e3181d56c98

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

Impaired locomotor activity and spatial memory are common features in the natural aging process, and aging is an important risk factor for neurodegenerative disease and postoperative cognitive dysfunction. To characterize age-related changes in psychomotor performance, we assessed sensorimotor activity, spatial learning, and memory in C57BL/6 mice using the Rotarod, foot fault, and Barnes Maze tests. Old mice exhibit significant deficits in locomotor activity and spatial memory relative to young mice, but improve with training. These tests will be useful to assess outcome in neurodegenerative disease and postoperative cognitive dysfunction models carried out in aged mice.

引用

收藏

页码：214 / 219

页数：6

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