Is pH a biochemical marker of IQ?

被引:38
作者
Rae, C [1 ]
Scott, RB [1 ]
Thompson, CH [1 ]
Kemp, GJ [1 ]
Dumughn, I [1 ]
Styles, P [1 ]
Tracey, I [1 ]
Radda, GK [1 ]
机构
[1] RADCLIFFE INFIRM, DEPT NEUROSURG, RUSSELL CAIRNS UNIT, OXFORD OX2 6HE, ENGLAND
关键词
D O I
10.1098/rspb.1996.0156
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have measured intracellular brain pH in vivo in 42 boys and found a significant correlation between this biochemical parameter and samples of intelligent behaviour. To the best of our knowledge this is the first reported relation between a biochemical marker which is within normal physiological values and intellectual ability. pH is one of the most accurate parameters that can be measured by P-31 magnetic resonance spectroscopy and it reflects sensitively cellular ionic status and metabolic activity. The observed correlation, although not implying a causal relation, raises the possibility that intelligent behaviour may be influenced by the ionic status of brain tissue, or vice versa.
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收藏
页码:1061 / 1064
页数:4
相关论文
共 26 条
[1]  
BRACKEN BA, 1993, J PSYCHOEDUCATIONAL
[2]   DEVELOPMENTAL-CHANGES OF PHOSPHORUS METABOLITE CONCENTRATIONS IN THE HUMAN BRAIN - A P-31 MAGNETIC-RESONANCE SPECTROSCOPY STUDY IN-VIVO [J].
BUCHLI, R ;
MARTIN, E ;
BOESIGER, P ;
RUMPEL, H .
PEDIATRIC RESEARCH, 1994, 35 (04) :431-435
[3]   HUMAN PRIMARY BRAIN-TUMOR METABOLISM INVIVO - A PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY STUDY [J].
CADOUXHUDSON, TAD ;
BLACKLEDGE, MJ ;
RAJAGOPALAN, B ;
TAYLOR, DJ ;
RADDA, GK .
BRITISH JOURNAL OF CANCER, 1989, 60 (03) :430-436
[4]  
CALLAWAY E, 1973, ARCH GEN PSYCHIAT, V29, P553
[5]   INTRACELLULAR PH OF ASTROCYTES INCREASES RAPIDLY WITH CORTICAL STIMULATION [J].
CHESLER, M ;
KRAIG, RP .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (04) :R666-R670
[6]   MODULATION OF PH BY NEURONAL-ACTIVITY [J].
CHESLER, M ;
KAILA, K .
TRENDS IN NEUROSCIENCES, 1992, 15 (10) :396-402
[7]   SOME EFFECTS OF PCO2 AND PH ON NERVE TISSUE [J].
ELLIS, FR .
BRITISH JOURNAL OF PHARMACOLOGY, 1969, 35 (01) :197-&
[8]   BRAIN RESPONSE CORRELATES OF PSYCHOMETRIC INTELLIGENCE [J].
ERTL, JP ;
SCHAFER, EWP .
NATURE, 1969, 223 (5204) :421-&
[9]  
FARAH M, 1994, J EXP PSYCHOL, V120, P339
[10]   ENDOGENOUS H+ MODULATION OF NMDA RECEPTOR-MEDIATED EPSCS REVEALED BY CARBONIC-ANHYDRASE INHIBITION IN RAT HIPPOCAMPUS [J].
GOTTFRIED, JA ;
CHESLER, M .
JOURNAL OF PHYSIOLOGY-LONDON, 1994, 478 (03) :373-378