Evaluation of ST-segment changes during and after maximal exercise tests in one-, two- and three-vessel coronary artery disease

被引:6
作者
Bjurö, T
Gullestad, L
Endresen, K
Nordlander, M
Malm, AR
Höglund, L
Wahlqvist, I
Pernow, J
机构
[1] AstraZeneca R&D, SE-43183 Molndal, Sweden
[2] Baerum Hosp, Dept Internal Med, Oslo, Norway
[3] Rikshosp Univ Hosp, Dept Cardiol, Oslo, Norway
[4] Karolinska Hosp, Dept Cardiol, Stockholm, Sweden
关键词
coronary angiography; exercise test; heart rate recovery; post-exercise ST-segment slope; ST/HR recovery loop; ST/HR slope; time to > 1 mm ST-depression;
D O I
10.1080/14017430410021606
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-To relate ECG and heart rate (HR) variables during and after exercise testing with the presence of one- ,two- or three-vessel disease defined by angiography. Design-Seventy-three male patients with stable angina pectoris and angiographically verified coronary artery disease underwent a maximal exercise test. From 12-lead ECG recordings and computer averaging ST-amplitude and HR data were measured in consecutive 10-s intervals. Results-In univariate analysis, patients with three-vessel disease had lower maximal exercise capacity, a shorter time to >1 mm ST-depression, more often a clockwise ST/HR recovery loop, more frequently a post-exercise downward ST-segment slope, and a greater ST-deficit at 3.5 min after exercise than patients with one- vessel disease. In multivariate analysis, time to >1 mm ST-depression discriminated between patients with three- and one- vessel disease. In patients with an intermediate time to >1 mm ST-depression a clockwise ST/HR recovery loop and/or a downsloping ST-segment in the post-exercise period were significantly more prevalent in severe vessel disease. Conclusion-Patients with three-vessel disease had a significantly shorter time to >1 mm ST-depression during exercise and more often an abnormal post-exercise ST/HR reaction than those with one-vessel disease.
引用
收藏
页码:270 / 277
页数:8
相关论文
共 23 条
[1]   Significance of ST-segment morphology noted on electrocardiography during the recovery phase after exercise in patients with ischemic heart disease as analyzed with simultaneous dualisotope single photon emission tomography [J].
Akutsu, Y ;
Shinozuka, A ;
Nishimura, H ;
Li, HL ;
Huang, TY ;
Yamanaka, H ;
Takenaka, H ;
Munechika, H ;
Katagiri, T .
AMERICAN HEART JOURNAL, 2002, 144 (02) :335-342
[2]   Exercise versus recovery electrocardiography in predicting mortality in patients with uncomplicated myocardial infarction [J].
Bigi, R ;
Cortigiani, L ;
Gregori, D ;
De Chiara, B ;
Fiorentini, C .
EUROPEAN HEART JOURNAL, 2004, 25 (07) :558-564
[3]   A reappraisal of exercise electrocardiographic indexes of the severity of ischemic heart disease: Angiographic and scintigraphic correlates [J].
Bogaty, P ;
Guimond, J ;
Robitaille, NM ;
Rousseau, L ;
Simard, S ;
Rouleau, JR ;
Dagenais, GR .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1997, 29 (07) :1497-1504
[4]   Antianginal and antiischemic effects of ivabradine, an If inhibitor, in stable angina -: A randomized, double-blind, multicentered, placebo-controlled trial [J].
Borer, JS ;
Fox, K ;
Jaillon, P ;
Lerebours, G .
CIRCULATION, 2003, 107 (06) :817-823
[5]  
BRUCE RA, 1969, B NEW YORK ACAD MED, V45, P1288
[6]   Heart-rate recovery immediately after exercise as a predictor of mortality [J].
Cole, CR ;
Blackstone, EH ;
Pashkow, FJ ;
Snader, CE ;
Lauer, MS .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (18) :1351-1357
[7]   The value of routine non-invasive tests to predict clinical outcome in stable angina [J].
Daly, C ;
Norrie, J ;
Murdoch, DL ;
Ford, I ;
Dargie, HJ ;
Fox, K .
EUROPEAN HEART JOURNAL, 2003, 24 (06) :534-542
[8]   Prolonged ST segment depression after stress testing:: does it really identify more severe disease? [J].
Desai, MY ;
De la Peña-Almaguer, E ;
Mannting, F .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2003, 87 (01) :59-66
[9]   Predicting severe angiographic coronary artery disease using computerization of clinical and exercise test data [J].
Do, D ;
Marcus, R ;
Froelicher, V ;
Janosi, A ;
West, J ;
Atwood, JE ;
Myers, J ;
Chilton, R ;
Froning, J .
CHEST, 1998, 114 (05) :1437-1445
[10]  
FALK KJ, 1982, MED PROG TECHNOL, V8, P159