Aspects of PET imaging relevant to the assessment of striatal transplantation in Huntington's disease

被引：7

作者：

Besret, L ^{[1
]}

Kendall, AL ^{[1
]}

Dunnett, SB ^{[1
]}

机构：

[1] Univ Cambridge, Ctr Brain Repair, Cambridge CB2 1TN, England

来源：

JOURNAL OF ANATOMY | 2000年 / 196卷

关键词：

Huntington's disease; striatal transplantation; PET imaging;

D O I：

10.1046/j.1469-7580.2000.19640597.x

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Proper assessment of outcome in clinical trials of neural transplantation requires both biochemical and imaging indices of graft survival, and behavioural and physiological indices of graft function. For transplantation in Huntington's disease, a variety of ligands that are selective for striatal degeneration and graft-derived replacement are available, notably ligands of dopaminergic receptors on striatal neurons. However, the validity of such ligands is potentially compromised by adjunctive drug therapies (e.g. neuroleptics) given to patients in the course of normal clinical care. We review the present state of experimental and clinical understanding of the selectivity of available ligands for striatal imaging, their interaction with other drug treatments, and strategies for refining valid assessment protocols in patients.

引用

页码：597 / 607

页数：11

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