The zebrafish retinoid-related orphan receptor (ror) gene family

被引：40

作者：

Flores, Maria Vega ^{[1
]}

Hall, Christopher ^{[1
]}

Jury, Alexa ^{[1
]}

Crosier, Kathryn ^{[1
]}

Crosier, Philip ^{[1
]}

机构：

[1] Univ Auckland, Sch Med Sci, Dept Mol Med & Pathol, Auckland 1, New Zealand

来源：

GENE EXPRESSION PATTERNS | 2007年 / 7卷 / 05期

关键词：

Rora; Rorb; Rorc; retinoid-related orphan receptors; phylogeny; synteny; zebrafish; pineal gland; retina; gut; maternal transcript;

D O I：

10.1016/j.modgep.2007.02.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The retinoid-related orphan receptors Rora, b and c are highly conserved transcription factors belonging to the steroid hormone receptor superfamily. Mammalian ROR proteins perform key regulatory roles in a number of processes during embryonic development and in the adult including neurogenesis, bone metabolism and modulation of circadian rhythms. A more recent area of interest has been their roles in the development and function of the immune system. In particular, RORA has been implicated in the regulation of inflammatory cytokine production, and RORC has been shown to be essential in the development of the T lymphocyte repertoire and of secondary lymphoid organs. We cloned the zebrafish orthologs for the Ror gene family. Assignment of orthologies was supported by analysis of the phylogenetic relationships between zebrafish and other vertebrate Ror genes based on sequence similarities, and conserved syntenies with the human Ror gene loci. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：535 / 543

页数：9

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