Interconversion of single and double helices formed from synthetic molecular strands

被引:630
作者
Berl, V
Huc, I
Khoury, RG
Krische, MJ
Lehn, JM
机构
[1] Univ Strasbourg 1, ISIS, Lab Chim Supramol, F-67000 Strasbourg, France
[2] Forschungszentrum Karlsruhe GmbH, Inst Nanotechnol, D-76021 Karlsruhe, Germany
[3] ENSCPB, Inst Europeen Chim & Biol, F-33402 Talence, France
关键词
D O I
10.1038/35037545
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Synthetic single-helical conformations are quite common, but the formation of double helices based on recognition between the two constituent strands is relatively rare. Known examples include duplex formation through base-pair-specific hydrogen bonding and stacking, as found in nucleic acids and their analogues, and polypeptides composed of amino acids with alternating L and D configurations(1,2). Some synthetic polymers(3) and self-assembled fibres(4) have double-helical winding induced by van der Waals interactions. A third mode of non-covalent interaction, coordination of organic ligands to metal ions(5-7), can give rise to double, triple and quadruple helices, although in this case the assembly is driven by the coordination geometry of the metal and the structure of the ligands, rather than by direct inter-strand complementarity. Here we describe a family of oligomeric molecules with bent conformations, which exhibit dynamic exchange between single and double molecular helices in solution, through spiral sliding of the synthetic oligomer strands. The bent conformations leading to the helical shape of the molecules result from intramolecular hydrogen bonding within 2'-pyridyl-2-pyridinecarboxamide units(8-12), with extensive intermolecular aromatic stacking stabilizing the double-stranded helices that form through dimerization.
引用
收藏
页码:720 / 723
页数:5
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