Coronary thrombosis and sudden death after an enteroviral infection

被引：4

作者：

Calabrese, F ^{[1
]}

Basso, C ^{[1
]}

Valente, M ^{[1
]}

Thiene, G ^{[1
]}

机构：

[1] Univ Padua, Sch Med, Dept Pathol, Padua, Italy

来源：

APMIS | 2003年 / 111卷 / 02期

关键词：

coronary thrombosis; sudden death; enteroviral infection;

D O I：

10.1034/j.1600-0463.2003.1110204.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the case of a 26-year-old man who died suddenly 9 days after an episode of flu. Microscopic examination of the left anterior descending coronary artery showed an eccentric fibroatheromatic plaque complicated by thrombosis, endothelial erosion and extensive T-cell and macrophage infiltration. Frozen sections of the thrombotic coronary segment, analysed for different infective agents by polymerase chain reaction (PCR) and reverse transcriptase (RT)-PCR, showed positive amplification for an enteroviral genome. Enteroviral infection may play an important role in coronary plaque instability and may precipitate thrombotic occlusion.

引用

收藏

页码：315 / 318

页数：4

相关论文

共 20 条

[1] VIRUSES IN THE ETIOLOGY OF ATHEROSCLEROSIS [J].

BENDITT, EP ;

BARRETT, T ;

MCDOUGALL, JK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (20) :6386-6389

[2]

BURCH GE, 1977, BRIT J EXP PATHOL, V58, P565

[3] Molecular diagnosis of myocarditis and dilated cardiomyopathy in children: Clinicopathologic features and prognostic implications [J].

Calabrese, F ;

Rigo, E ;

Milanesi, O ;

Boffa, GM ;

Angelini, A ;

Valente, M ;

Thiene, G .

DIAGNOSTIC MOLECULAR PATHOLOGY, 2002, 11 (04) :212-221

[4] Persistent infection of human vascular endothelial cells by group B coxsackieviruses [J].

Conaldi, PG ;

Serra, C ;

Mossa, A ;

Falcone, V ;

Basolo, F ;

Camussi, G ;

Dolei, A ;

Toniolo, A .

JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (03) :693-696

[5] SUDDEN-DEATH IN THE YOUNG - IS ACUTE CORONARY-THROMBOSIS THE MAJOR PRECIPITATING FACTOR [J].

CORRADO, D ;

BASSO, C ;

POLETTI, A ;

ANGELINI, A ;

VALENTE, M ;

THIENE, G .

CIRCULATION, 1994, 90 (05) :2315-2323

[6] Stability and instability: Two faces of coronary atherosclerosis - The Paul Dudley White Lecture 1995 [J].

Davies, MJ .

CIRCULATION, 1996, 94 (08) :2013-2020

[7] Enterovirus RNA replication in cases of dilated cardiomyopathy: Light microscopic in situ hybridization and virological analyses of myocardial specimens obtained at partial left ventriculectomy [J].

Deguchi, H ;

Fujioka, S ;

Terasaki, F ;

Ukimura, A ;

Hirasawa, M ;

Kintaka, T ;

Kitaura, Y ;

Kondo, K ;

Sasaki, S ;

Isomura, T ;

Suma, H .

JOURNAL OF CARDIAC SURGERY, 2001, 16 (01) :64-71

[8] Infection and coronary heart disease [J].

Ellis, RW .

JOURNAL OF MEDICAL MICROBIOLOGY, 1997, 46 (07) :535-539

[9]

Klingel K, 1998, LAB INVEST, V78, P1227

[10] DEMONSTRATION OF CHLAMYDIA-PNEUMONIAE IN ATHEROSCLEROTIC LESIONS OF CORONARY-ARTERIES [J].

KUO, CC ;

SHOR, A ;

CAMPBELL, LA ;

FUKUSHI, H ;

PATTON, DL ;

GRAYSTON, JT .

JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (04) :841-849