Wnt/β-catenin signaling and cardiogenesis:: Timing does matter

被引：154

作者：

Tzahor, Eldad ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel

来源：

DEVELOPMENTAL CELL | 2007年 / 13卷 / 01期

关键词：

D O I：

10.1016/j.devcel.2007.06.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Recent findings in mouse and zebrafish embryos, as well as in embryonic stem cells, emphasize the critical importance of the Wnt/beta-catenin pathway in the regulation of cardiogenesis, and highlight the exquisite timing and specific cellular responses by which this signaling pathway exerts its influence. These studies clearly demonstrate that the Wnt/beta-catenin pathway plays distinct, even opposing, roles during various stages of cardiac development.

引用

收藏

页码：10 / 13

页数：4

相关论文

共 13 条

[1]

Canonical Wnt signaling functions in second heart field to promote right ventricular growth [J].

Ai, Di ;

Fu, Xueyao ;

Wang, Jun ;

Lu, Mei-Fang ;

Chen, Li ;

Baldini, Antonio ;

Klein, William H. ;

Martin, James F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (22) :9319-9324

[2]

Building the mammalian heart from two sources of myocardial cells [J].

Buckingham, M ;

Meilhac, S ;

Zaffran, S .

NATURE REVIEWS GENETICS, 2005, 6 (11) :826-835

[3]

Wnt/β-catenin signaling promotes expansion of Isl-1 -: positive cardiac progenitor cells through regulation of FGF signaling [J].

Cohen, Ethan David ;

Wang, Zhishan ;

Lepore, John J. ;

Lu, Min Min ;

Taketo, Makoto M. ;

Epstein, Douglas J. ;

Morrisey, Edward E. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (07) :1794-1804

[4]

Wnt signal transduction and the formation of the myocardium [J].

Eisenberg, Leonard M. ;

Eisenberg, Carol A. .

DEVELOPMENTAL BIOLOGY, 2006, 293 (02) :305-315

[5]

Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors [J].

Kwon, Chulan ;

Arnold, Joshua ;

Hsiao, Edward C. ;

Taketo, Makoto M. ;

Conklin, Bruce R. ;

Srivastava, Deepak .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (26) :10894-10899

[6]

β-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis [J].

Lin, Lizhu ;

Cui, Li ;

Zhou, Wenlai ;

Dufort, Daniel ;

Zhang, Xiaoxue ;

Cai, Chen-Leng ;

Bu, Lei ;

Yang, Lei ;

Martin, Jody ;

Kemler, Rolf ;

Rosenfeld, Michael G. ;

Chen, Ju ;

Evans, Sylvia M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (22) :9313-9318

[7]

Inhibition of Wnt activity induces heart formation from posterior mesoderm [J].

Marvin, MJ ;

Di Rocco, G ;

Gardiner, A ;

Bush, SM ;

Lassar, AB .

GENES & DEVELOPMENT, 2001, 15 (03) :316-327

[8]

Developmental stage-specific biphasic roles of Wnt/β-catenin signaling in cardiomyogenesis and hematopoiesis [J].

Naito, Atsuhiko T. ;

Shiojima, Ichiro ;

Akazawa, Hiroshi ;

Hidaka, Kyoko ;

Morisaki, Takayuki ;

Kikuchi, Akira ;

Komuro, Issei .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (52) :19812-19817

[9]

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation [J].

Prall, Owen W. J. ;

Menon, Mary K. ;

Solloway, Mark J. ;

Watanabe, Yusuke ;

Zaffran, Stephane ;

Bajolle, Fanny ;

Biben, Christine ;

McBride, Jim J. ;

Robertson, Bronwyn R. ;

Chaulet, Herve ;

Stennard, Fiona A. ;

Wise, Natalie ;

Schaft, Daniel ;

Wolstein, Orit ;

Furtado, Milena B. ;

Shiratori, Hidetaka ;

Chien, Kenneth R. ;

Hamada, Hiroshi ;

Black, Brian L. ;

Saga, Yumiko ;

Robertson, Elizabeth J. ;

Buckingham, Margaret E. ;

Harvey, Richard P. .

CELL, 2007, 128 (05) :947-959

[10]

QYANG Y, 2007, IN PRESS CELL STEM C, DOI DOI 10.1016/J.STEM2007.05.018