Troglitazone reduces plasma levels of tumour necrosis factor-α in obese patients with type 2 diabetes

被引：36

作者：

Katsuki, A ^{[1
]}

Sumida, Y ^{[1
]}

Murata, K ^{[1
]}

Furuta, M ^{[1
]}

Araki-Sasaki, R ^{[1
]}

Tsuchihashi, K ^{[1
]}

Hori, Y ^{[1
]}

Yano, Y ^{[1
]}

Gabazza, EC ^{[1
]}

Adachi, Y ^{[1
]}

机构：

[1] Mie Univ, Sch Med, Dept Internal Med 3, Tsu, Mie 5148507, Japan

来源：

DIABETES OBESITY & METABOLISM | 2000年 / 2卷 / 03期

关键词：

troglitazone; tumour necrosis factor-alpha; obesity; type; 2; diabetes;

D O I：

10.1046/j.1463-1326.2000.00072.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the effect of troglitazone (given orally 400 mg/day) on glucose intolerance and on the plasma levels of tumour necrosis factor-alpha (TNF-alpha) in 12 obese patients with type 2 diabetes for 12 weeks. Troglitazone significantly decreased fasting plasma glucose, serum C-peptide, serum insulin and HbA(1c) levels. Plasma levels of TNF-alpha were significantly reduced by troglitazone administered for 8 and 12 weeks. Troglitazone administration significantly improved insulin resistance, but did not affect pancreatic beta-cell function as evaluated by the homeostasis model assessment (HOMA). In the present study, we reported for the first time that troglitazone administration significantly reduces plasma levels of TNF-alpha in obese patients with type 2 diabetes.

引用

页码：189 / 191

页数：3

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