Protection against post-ischaemic neuronal loss in gerbil hippocampal CA1 by glycineB and AMPA antagonists

被引：18

作者：

Lazarewicz, JW

Gadamski, R

Parsons, CG

Danysz, W

机构：

[1] Polish Acad Sci, Med Res Ctr, PL-02106 Warsaw, Poland

[2] Merz & Co, Dept Pharmacol, Frankfurt, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 1997年 / 104卷 / 11-12期

关键词：

forebrain ischaemia; gerbil; glycine; antagonists; MRZ; 2/570; 2/576; NBQX; hippocampus;

D O I：

10.1007/BF01294724

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Novel antagonists of the glycine, site of the NMDA receptor (MRZ 2/570, MRZ 2/576), and an AMPA receptor antagonist, NBQX were tested in 3-min. global ischaemia in gerbils. Untreated animals showed after 14 days a loss of almost 90% of pyramidal neurones in the CA1 region, which was prevented by NBQX, and reduced to 50% by both glycine, antagonists. NBQX produced a delayed, long lasting (up to 24 hr) hypothermia while hypothermia with both glycine(B) antagonists was transient.

引用

页码：1249 / 1254

页数：6

共 15 条

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BUCHAN A, 1990, J NEUROSCI, V10, P311

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