Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis

被引：1439

作者：

Dobereiner, Graham E. ^{[1
]}

Crabtree, Robert H. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

CHEMICAL REVIEWS | 2010年 / 110卷 / 02期

关键词：

ALDEHYDE OXIDATION LEVEL; ASTERISK-IR COMPLEX; C BOND FORMATION; HYDROGEN-TRANSFER-REACTIONS; N-HETEROCYCLIC CARBENE; FRIEDLANDER QUINOLINE SYNTHESIS; FORMING TRANSFER HYDROGENATION; OPPENAUER-TYPE OXIDATION; CHELATION-ASSISTED HYDROACYLATION; BASE-MEDIATED SYNTHESIS;

D O I：

10.1021/cr900202j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study was conducted to demonstrate dehydrogenation as a substrate-activating strategy in homogeneous transition-metal catalysis. It was found that the substrate was activated by catalytic dehydrogenative oxidation that was followed by a bond construction step. These steps proceeded under 'one-pot' conditions with a single catalyst or two catalysts acting together. It was observed that the two catalysts required for the metathesis step and for the dehydrogenation and hydrogenation steps did not interfere with each. The study also demonstrated that the dehydrogenation step had the potential to function as a mode of alcohol activation along with performing C-H bond activation.

引用

页码：681 / 703

页数：23

共 291 条

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