Orthopaedic metals and their potential toxicity in the arthroplasty patient - Review of current knowledge and future strategies

被引：248

作者：

Keegan, G. M. ^{[1
]}

Learmonth, I. D. ^{[1
]}

Case, C. P. ^{[1
]}

机构：

[1] Univ Bristol, Southmead Hosp, Bristol Implant Res Ctr, Avon Orthopaed Ctr, Bristol BS10 5NB, Avon, England

来源：

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME | 2007年 / 89B卷 / 05期

关键词：

D O I：

10.1302/0301-620X.89B5.18903

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The long-term effects of metal-on-metal arthroplasty are currently under scrutiny because of the potential biological effects of metal wear debris. This review summarises data describing the release, dissemination, uptake, biological activity, and potential toxicity of metal wear debris released from alloys currently used in modern orthopaedics. The introduction of risk assessment for the evaluation of metal alloys and their use in arthroplasty patients is discussed and this should include potential harmful effects on immunity, reproduction, the kidney, developmental toxicity, the nervous system and carcinogenesis.

引用

页码：567 / 573

页数：7

共 119 条

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