Disruption of cellular transport: a common cause of neurodegeneration?

被引：21

作者：

Crosby, AH ^{[1
]}

机构：

[1] Univ London St Georges Hosp, Sch Med, Dept Med Genet, London SW17 0RE, England

来源：

LANCET NEUROLOGY | 2003年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1474-4422(03)00383-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In many cases, the clinical manifestations of inherited neurodegenerative disorders appear after decades of normal function, which suggests that neurons may die through cumulative damage. Several genes that cause these diseases have been identified in recent years, but no common pathogenetic mechanism has been found. However, the most recent studies have begun to implicate the same mechanism in a range of neurodegenerative diseases, particularly those that involve motor neurons. The results of these studies suggest that the morphology and energy requirements of neurons make them particularly susceptible to the disruption of cellular transport systems.

引用

页码：311 / 316

页数：6

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