Antimicrobial peptide microbicides targeting HIV

被引：23

作者：

Cole, AM ^{[1
]}

机构：

[1] Univ Cent Florida, Biomol Sci Ctr, Dept Mol Biol & Microbiol, Orlando, FL 32816 USA

来源：

PROTEIN AND PEPTIDE LETTERS | 2005年 / 12卷 / 01期

关键词：

antimicrobial; peptide; defensin; HIV-1; cathelicidin; human; minidefensin; STD;

D O I：

10.2174/0929866053406101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cationic antimicrobial peptides and proteins are among the earliest molecular effectors of the innate arm of immunity in humans and other vertebrates. This review, inspired by recent emphasis on the development of topical preventatives for sexually transmitted infections, describes antimicrobial peptides and proteins in the context of microbicide design and development. Particular emphasis is placed on the defensin family of peptides.

引用

页码：41 / 47

页数：7

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