The effect of race/ethnicity on the outcome of highly active antiretroviral therapy for human immunodeficiency virus type 1-infected patients

被引:67
作者
Jensen-Fangel, S
Pedersen, L
Pedersen, C
Larsen, CS
Tauris, P
Moller, A
Sorensen, HT
Obel, N
机构
[1] Aarhus Univ Hosp, Dept Infect Dis, DK-8000 Aarhus, Denmark
[2] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark
[3] Odense Univ Hosp, Dept Infect Dis, DK-5000 Odense, Denmark
[4] Aalborg Hosp, Dept Infect Dis, Aalborg, Denmark
[5] Herming Hosp, Dept Infect Dis, Heming, Denmark
[6] Kolding Cty Hosp, Dept Infect Dis, Kolding, Denmark
关键词
D O I
10.1086/344769
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We performed a population- based cohort study to assess the impact of nonwhite origin on the outcome of highly active antiretroviral therapy (HAART) for a Danish cohort of human immunodeficiency virus (HIV)- infected patients. A total of 389 whites and 135 nonwhites started receiving HAART before 1 April 2001. After 1 year of treatment, 78% of nonwhites and 76% of whites achieved a virus load of < 500 HIV RNA copies/ mL. No major differences were found between the 2 groups with respect to achievement of a virus load of < 500 copies/ mL (relative risk [RR], 0.94; 95% confidence interval [CI], 0.74- 1.18), risk of clinical progression (RR, 0.63; 95% CI, 0.32- 1.24), or response measured by total CD4(+) cell count. One year after fulfilling Danish recommendations for initiation of HAART, 91% of nonwhites and 93% of whites had started receiving HAART. Race and ethnic origin play no major role in the outcome associated with HAART if access to health care is free.
引用
收藏
页码:1541 / 1548
页数:8
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