Effects of sex steroid hormones and menopause on serum leptin concentrations

被引:41
作者
Di Carlo, C [1 ]
Tommaselli, GA [1 ]
Nappi, C [1 ]
机构
[1] Univ Naples Federico II, Dept Obstet & Gynecol, I-80131 Naples, Italy
关键词
leptin; sex steroids; menopause; hormone replacement therapy;
D O I
10.1080/gye.16.6.479.491
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Leptin is a protein secreted by adipocytes; its circulating levels are correlated to fat mass and it acts on the hypothalamic centers regulating body weight. Leptin may also play an important role in regulating reproductive function. Indeed, ob/ob mice, lacking leptin due to a genetic mutation, are obese and infertile; administration Of recombinant leptin to these animals reduces body weight and restores fertility. A sexual dimorphism in serum leptin levels has also been observed, with higher concentrations in women. Studies in vitro seem to indicate that estrogens stimulate leptin secretion, while in vivo studies are extremely discordant. In humans, several studies showed increased, unmodified and decreased leptin levels after the menopause. Furthermore, hormonal replacement therapy (HRT) after the menopause was reported to result in unmodified, increased or decreased leptin levels. It is likely that the effects of postmenopausal hypoestrogenism on leptin levels are masked by the postmenopausal changes in body composition. Indeed, after menopause, there is an increase in body weight, body mass index (BMI) and fat mass with a centralization of fat distribution. Administration of HRT may stop these changes and even restore a premenopausal pattern, leading then to decreased leptin levels.
引用
收藏
页码:479 / 491
页数:13
相关论文
共 128 条
[1]   THE INFLUENCE OF MENOPAUSE AND HORMONAL REPLACEMENT THERAPY ON BODY CELL MASS AND BODY-FAT MASS [J].
ALOIA, JF ;
VASWANI, A ;
RUSSO, L ;
SHEEHAN, M ;
FLASTER, E .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1995, 172 (03) :896-900
[2]   Relation of race, age, and sex hormone differences to serum leptin concentrations in children and adolescents [J].
Ambrosius, WT ;
Compton, JA ;
Bowsher, RR ;
Pratt, JH .
HORMONE RESEARCH, 1998, 49 (05) :240-246
[3]   Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa [J].
Argente, J ;
Barrios, V ;
Chowen, JA ;
Sinha, MK ;
Considine, RV .
JOURNAL OF PEDIATRICS, 1997, 131 (06) :833-838
[4]   Plasma leptin in children: Relationship to puberty, gender, body composition, insulin sensitivity, and energy expenditure [J].
Arslanian, S ;
Suprasongsin, C ;
Kalhan, SC ;
Drash, AL ;
Brna, R ;
Janosky, JE .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (03) :309-312
[5]   Relationship among leptin, neuropeptide Y, and galanin in young women and in postmenopausal women [J].
Baranowska, B ;
Radzikowska, M ;
Wasilewska-Dziubínska, E ;
Roguski, K ;
Polonowski, A .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2000, 7 (03) :149-155
[6]   Leptin is a metabolic signal to the reproductive system [J].
Barash, IA ;
Cheung, CC ;
Weigle, DS ;
Ren, HP ;
Kabigting, EB ;
Kuijper, JL ;
Clifton, DK ;
Steiner, RA .
ENDOCRINOLOGY, 1996, 137 (07) :3144-3147
[7]   Regulation of leptin gene expression and secretion by steroid hormones [J].
Brann, DW ;
De Sevilla, L ;
Zamorano, PL ;
Mahesh, VB .
STEROIDS, 1999, 64 (09) :659-663
[8]   FOOD-INTAKE AND THE MENSTRUAL-CYCLE - A RETROSPECTIVE ANALYSIS, WITH IMPLICATIONS FOR APPETITE RESEARCH [J].
BUFFENSTEIN, R ;
POPPITT, SD ;
MCDEVITT, RM ;
PRENTICE, AM .
PHYSIOLOGY & BEHAVIOR, 1995, 58 (06) :1067-1077
[9]   THE ENDOCRINOLOGY OF THE MENOPAUSAL TRANSITION - A CROSS-SECTIONAL STUDY OF A POPULATION-BASED SAMPLE [J].
BURGER, HG ;
DUDLEY, EC ;
HOPPER, JL ;
SHELLEY, JM ;
GREEN, A ;
SMITH, A ;
DENNERSTEIN, L ;
MORSE, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (12) :3537-3545
[10]   SLOWING OF PULSATILE LUTEINIZING-HORMONE SECRETION IN MEN AFTER 48 HOURS OF FASTING [J].
CAMERON, JL ;
WELTZIN, TE ;
MCCONAHA, C ;
HELMREICH, DL ;
KAYE, WH .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (01) :35-41