The Staphylococcus aureus "superbug"

被引:231
作者
Foster, TJ [1 ]
机构
[1] Univ Dublin Trinity Coll, Moyne Inst Prevent Med, Dept Microbiol, Dublin 2, Ireland
关键词
D O I
10.1172/JCI200423825
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
There has been some debate about the disease-invoking potential of Staphylococcus aureus strains and whether invasive disease is associated with particularly virulent genotypes, or "superbugs." A study in this issue of the JCI describes the genotyping of a large collection of nonclinical, commensal S. aureus strains from healthy individuals in a Dutch population. Extensive study of their genetic relatedness by amplified restriction fragment typing and comparison with strains that are associated with different types of infections revealed that the S. aureus population is clonal and that some strains have enhanced virulence (see the related article beginning on page 1732). This is discussed in the context of growing interest in the mechanisms of bacterial colonization, antibiotic resistance, and novel vaccines.
引用
收藏
页码:1693 / 1696
页数:4
相关论文
共 29 条
[1]  
Bohach GA, 2000, GRAM-POSITIVE PATHOGENS, P367
[2]   Methicillin resistance in staphylococci: Molecular and biochemical basis and clinical implications [J].
Chambers, HF .
CLINICAL MICROBIOLOGY REVIEWS, 1997, 10 (04) :781-+
[3]   Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent [J].
de Haas, CJC ;
Veldkamp, KE ;
Peschel, A ;
Weerkamp, F ;
Van Wamel, WJB ;
Heezius, ECJM ;
Poppelier, MJJG ;
Van Kessel, KPM ;
van Strijp, JAG .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (05) :687-695
[4]   Quinupristin-dalfopristin and linezolid: Evidence and opinion [J].
Eliopoulos, GM .
CLINICAL INFECTIOUS DISEASES, 2003, 36 (04) :473-481
[5]   The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA) [J].
Enright, MC ;
Robinson, DA ;
Randle, G ;
Feil, EJ ;
Grundmann, H ;
Spratt, BG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (11) :7687-7692
[6]   Development of StaphVAX™, a polysaccharide conjugate vaccine against S-aureus infection:: from the lab bench to phase III clinical trials [J].
Fattom, AI ;
Horwith, G ;
Fuller, S ;
Propst, M ;
Naso, R .
VACCINE, 2004, 22 (07) :880-887
[7]   Bacterial evasion of innate host defenses -: the Staphylococcus aureus lesson [J].
Fedtke, I ;
Götz, F ;
Peschel, A .
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2004, 294 (2-3) :189-194
[8]   How clonal is Staphylococcus aureus? [J].
Feil, EJ ;
Cooper, JE ;
Grundmann, H ;
Robinson, DA ;
Enright, MC ;
Berendt, T ;
Peacock, SJ ;
Smith, JM ;
Murphy, M ;
Spratt, BG ;
Moore, CE ;
Day, NPJ .
JOURNAL OF BACTERIOLOGY, 2003, 185 (11) :3307-3316
[9]   Surface protein adhesins of Staphylococcus aureus [J].
Foster, TJ ;
Höök, M .
TRENDS IN MICROBIOLOGY, 1998, 6 (12) :484-488
[10]   Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients [J].
Gillet, Y ;
Issartel, B ;
Vanhems, P ;
Fournet, JC ;
Lina, G ;
Bes, M ;
Vandenesch, F ;
Piémont, Y ;
Brousse, N ;
Floret, D ;
Etienne, J .
LANCET, 2002, 359 (9308) :753-759