Pulmonary Alveolar Proteinosis in Workers at an Indium Processing Facility

被引：128

作者：

Cummings, Kristin J. ^{[1
]}

Donat, Walter E. ^{[2
]}

Ettensohn, David B. ^{[2
]}

Roggli, Victor L. ^{[3
]}

Ingram, Peter ^{[3
]}

Kreiss, Kathleen ^{[1
]}

机构：

[1] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA

[2] Brown Univ, Dept Med, Warren Alpert Med Sch, Providence, RI 02912 USA

[3] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2010年 / 181卷 / 05期

关键词：

pulmonary alveolar proteinosis; indium; TIN-OXIDE; EXPOSURE; ASSOCIATION; PARTICLES; PNEUMONIA; FIBROSIS; DUST; LUNG;

D O I：

10.1164/rccm.200907-1022CR

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Two cases of pulmonary alveolar proteinosis, including one death, occurred in workers at a facility producing indium-tin oxide (ITO), a compound used in recent years to make flat panel displays. Both workers were exposed to airborne ITO dust and had indium in lung tissue specimens. One worker was tested for autoantibodies to granulocytemacrophage-colonystimulating factor (GM-CSF) and found to have an elevated level. These cases suggest that inhalational exposure to ITO causes pulmonary alveolar proteinosis, which may occur via an autoimmune mechanism.

引用

页码：458 / 464

页数：7

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