Enrichment for loci identical-by-descent between pairs of mouse or human genomes by genomic mismatch scanning

被引：16

作者：

McAllister, L

Penland, L

Brown, PO

机构：

[1] Stanford Univ, Med Ctr, Div Cardiovasc Med, Stanford, CA 94305 USA

[2] Stanford Univ, Med Ctr, Dept Genet, Stanford, CA 94305 USA

[3] Stanford Univ, Med Ctr, Howard Hughes Med Inst, Stanford, CA 94305 USA

[4] Stanford Univ, Med Ctr, Dept Biochem, Stanford, CA 94305 USA

来源：

GENOMICS | 1998年 / 47卷 / 01期

关键词：

D O I：

10.1006/geno.1997.5083

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mapping genes that underlie complex genetic traits, including genes that determine susceptibility to common diseases, requires an efficient method for high-resolution genotyping. Single-nucleotide differences between pairs of allelic sequences from unrelated individuals occur approximately once in every kilobase. Genomic mismatch scanning (GMS), by analyzing numerous single-nucleotide polymorphisms in a single genome-wide step, offers a potentially powerful and efficient approach to linkage analysis. GMS, originally developed in a yeast system, is shown here to be applicable to the more complex mouse and human genomes. (C) 1998 Academic Press.

引用

页码：7 / 11

页数：5

共 12 条

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