Artificial dinuclear phosphoesterases

被引：138

作者：

Chin, J ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K5, Canada

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1997年 / 1卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(97)80046-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many elegant dinuclear transition metal and lathanide complexes that efficiently hydrolyze phosphate esters including RNA and DNA have been reported recently. In most cases, the dinuclear complexes are much more reactive than the corresponding mononuclear metal complexes. Furthermore, structural and kinetic data indicate that substantial rate acceleration for phosphate diester cleavage is obtained by bridging the dinuclear metal centers with the two phosphoryl oxygens. Interestingly, such bridging structures have recently been implicated in several metalloenzyme catalyzed phosphate hydrolyses.

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页码：514 / 521

页数：8

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