Experimental Nipah virus infection in pteropid bats (Pteropus poliocephalus)

被引：195

作者：

Middleton, D. J. ^{[1
]}

Morrissy, C. J. ^{[1
]}

van der Heide, B. M. ^{[1
]}

Russell, G. M. ^{[1
]}

Braun, M. A. ^{[1
]}

Westbury, H. A. ^{[1
]}

Halpin, K. ^{[1
]}

Daniels, P. W. ^{[1
]}

机构：

[1] CSIRO Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2007年 / 136卷 / 04期

关键词：

Nipah virus; experimental infection; fruit bat; guinea-pig;

D O I：

10.1016/j.jcpa.2007.03.002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Seventeen grey-headed fruit bats (Pteropus poliocephalus) were inoculated subcutaneously with an isolate of Nipah virus derived from a fatally infected human. A control group of eight guinea-pigs was inoculated intraperitoneally with the same isolate in order to confirm virulence. Three of eight infected guinea-pigs developed clinical signs 7-9 days post-inoculation. Infected fruit bats developed a subclinical. infection characterized by the transient presence of virus within selected viscera, episodic viral excretion and seroconversion. A range of histopathological changes was observed within the tissues of infected bats. Nipah virus was excreted in bat urine while neutralizing antibody was present in serum. This intermittent, low-level excretion of Nipah virus in the urine of bats may be sufficient to sustain the net reproductive value of the virus in a species where there is regular urine contamination of the fur, mutual grooming, and where urine droplets are a feature of the environment. Crown Copyright (C) 2007 Published by Elsevier Ltd. All rights reserved.

引用

页码：266 / 272

页数：7

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