Rational design of a DNA wire possessing an extremely high hole transport ability

被引：71

作者：

Okamoto, A

Tanaka, K

Saito, I ^{[1
]}

机构：

[1] Kyoto Univ, Fac Engn, Dept Synthet Chem & Biol Chem, Kyoto 6068501, Japan

[2] Japan Sci & Technol Corp, SORST, Kyoto 6068501, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 17期

关键词：

D O I：

10.1021/ja0294008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA is a promising conductive biopolymer. However, there are problems that need to be solved to realize real DNA wires. These include the low efficiency of hole transport and the serious oxidative damage that can occur during hole transport. We have demonstrated a protocol for the design of a DNA wire that can effectively mediate hole transport that is not adversely affected by oxidation during hole transport through the DNA duplex. We have synthesized a stable and effective DNA wire by incorporating a designer nucleobase, benzodeazaadenine derivatives, which have lower oxidation potentials and wider stacking areas but are not decomposed during hole transport.

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页码：5066 / 5071

页数：6

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