Hormonal, lipoprotein, and vascular effects of the selective estrogen receptor modulator Raloxifene in hypercholesterolemic men

被引：11

作者：

Blum, A

Hathaway, L

Mincemoyer, R

Schenke, WH

Csako, G

Waclawiw, MA

Panza, JA

Connon, RO

机构：

[1] NHLBI, Cardiol Branch, Bethesda, MD 20892 USA

[2] NHLBI, Off Biostat Res, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 85卷 / 12期

关键词：

D O I：

10.1016/S0002-9149(00)00802-X

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

To determine whether a compound with estrogenic properties is of atherogenic lipoprotein and vascular benefit to men at risk for atherosclerosis, 24 hypercholesterolemic men took raloxifene 60 mg or placebo daily for 1 month in a double-blind study, with cross over to the alternate treatment after 1 month without therapy. Raloxifene caused no significant reduction in levels of atherogenic lipoproteins, did not improve brachial artery flow-mediated dilation, and did not reduce levels of soluble cell adhesion molecules associated with atherosclerosis.

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页码：1491 / +

页数：5

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