Synthesis of trifluoromethylpyrroles and related heterocycles from 4-ethyloxy-1,1,1-trifluorobut-3-ene-2-one

被引：51

作者：

Andrew, RJ ^{[1
]}

Mellor, JM ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON | 2000年 / 56卷 / 37期

关键词：

amino acids; pyrroles; thiaproline; trifluoromethyl;

D O I：

10.1016/S0040-4020(00)00598-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses cf intermediate 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones are described from 4-ethyloxy-1,1,1-trifluorobut-3-ene-2-one and alpha-aminoacids. In subsequent cyclisations pyrroles and other bicyclic heteroaromatics having trifluoromethyl substitution are obtained either by simple dehydration or with concomitant decarboxylation. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7267 / 7272

页数：6

共 53 条

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