Evidence of human immunodeficiency virus-associated lipodystrophy syndrome in children treated with protease inhibitors

被引：26

作者：

Bockhorst, JL

Ksseiry, I

Toye, M

Chipkin, SR

Stechenberg, BW

Fisher, DJ

Allen, HF

机构：

[1] Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA

[2] Baystate Med Ctr, Dept Pediat, Springfield, MA 01199 USA

[3] Baystate Med Ctr, Dept Med, Springfield, MA 01199 USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2003年 / 22卷 / 05期

关键词：

human immunodeficiency virus; protease inhibitor; lipodystrophy; cholesterol; insulin resistance;

D O I：

10.1097/00006454-200305000-00017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We conducted a prospective evaluation for evidence of the HIV-associated lipodystrophy syndrome of 26 children infected with HIV-1. Six children had evidence of body fat redistribution. Nine children showed laboratory evidence of insulin resistance. All children with body fat distribution or insulin resistance had been treated with protease inhibitors. Children treated with protease inhibitors had higher total cholesterol, higher low density lipoprotein-cholesterol and higher triglycerides than untreated children.

引用

收藏

页码：463 / 465

页数：3

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