Identification of the mouse homologue of human discs large and rat SAP97 genes

被引：9

作者：

Lin, LH ^{[1
]}

Sahr, KE ^{[1
]}

Chishti, AH ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, St Elizabeths Med Ctr, Tumor Cell Biol Lab, Boston, MA 02135 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1997年 / 1362卷 / 01期

关键词：

human Dlg; Drosophila Dlg; mouse Dlg; tumor suppressor gene; synapse-associated protein; MAGUK;

D O I：

10.1016/S0925-4439(97)00059-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human homologue of the Drosophila discs large (dlg) tumor suppressor gene encodes a 926 amino acid protein, hDlg, which is a member of the MAGUK (Membrane Associated GUanylate Kinase homologues) family of proteins. To facilitate the development of murine model system for functional studies in vivo, the primary structure of the mouse homologue of hDlg has been determined. Dlgh1 encodes a similar to 5.5 kb transcript that is ubiquitously expressed in murine tissues. Mouse mDlg is a 927 amino acid protein that is 95% identical to hDlg and 94% identical to rat synapse associated protein, SAP97. The unusually high conservation of the primary structure of murine and human Dlg proteins across their distinct protein domains suggests a conserved function in vivo. (C) 1997 Elsevier Science B.V.

引用

页码：1 / 5

页数：5

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