Synthesis of unsaturated esters from aldehydes: An inexpensive, practical alternative to the Horner-Emmons reaction under neutral conditions

被引：60

作者：

Ledford, BE ^{[1
]}

Carreira, EM ^{[1
]}

机构：

[1] CALTECH,ARNOLD & MABEL BECKMAN LABS CHEM SYNTHESIS,PASADENA,CA 91125

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 47期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)10182-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical, efficient, and mild process is described for the synthesis of unsaturated esters from aldehydes in good yields and diastereoselectivities. All of the reagents used in the protocol are commercially available at a nominal price: N2CHCO2Et, catalytic (1 mol%) ReOCl3(PPh3)(2), and (EtO)(3)P. Additionally, the reaction process can be carried out successfully in good yields (85%) and diastereoselectivities (>20:1) with reagent-grade solvent without prior purification of the reagents. (C) 1997 Elsevier Science Ltd.

引用

页码：8125 / 8128

页数：4

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