Endocrine functions of adipose tissue

被引：231

作者：

Waki, Hironori ^{[1
]}

Tontonoz, Peter

机构：

[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2007年 / 2卷

关键词：

adipokine; obesity; lipoatrophy; insulin resistance; inflammation; INDUCED INSULIN-RESISTANCE; TUMOR-NECROSIS-FACTOR; PLASMINOGEN-ACTIVATOR INHIBITOR-1; COMPLEMENT-RELATED PROTEIN; FATTY-ACID OXIDATION; NF-KAPPA-B; STEAROYL-COA DESATURASE-1; CORONARY-ARTERY-DISEASE; E-DEFICIENT MICE; TRANSGENIC MICE;

D O I：

10.1146/annurev.pathol.2.010506.091859

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Obesity is a risk factor for type 2 diabetes, dyslipidemia, and cardiovascular disease. Dissection of the molecular mechanisms underlying obesity and its relationship to insulin resistance and the metabolic syndrome are essential for developing new strategies for prevention and treatment of these disorders. Both excess adipose tissue and lack of adipose tissue cause insulin resistance and dyslipidemia, suggesting that normal fit is required for the maintenance of systemic glucose and lipid homeostasis. Recent advances in obesity research have led to the recognition that adipose tissue is an active endocrine organ that secretes multiple bioactive factors termed adipokines. Secretion of adipokines provides a link between adipose tissue lipid accumulation and the metabolic function of other tissues such as liver and muscle. Dysregulation of adipokines is emerging as an important mechanism by which adipose tissue contributes to systemic insulin resistance and metabolic disease.

引用

页码：31 / 56

页数：26

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