Factor XI as a target for antithrombotic therapy

被引：43

作者：

Bane, Charles E., Jr. ^{[1
]}

Gailani, David ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Pathol Microbiol & Immunol, Nashville, TN 37235 USA

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 09期

关键词：

COAGULATION-FACTOR-XI; FACTOR-IX; THROMBUS FORMATION; ANTISENSE OLIGONUCLEOTIDES; REDUCED INCIDENCE; INHIBITION; DEFICIENCY; ACTIVATION; PATHWAY; BINDING;

D O I：

10.1016/j.drudis.2014.05.018

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Anticoagulants currently used in clinical practice to treat thromboembolic disorders are effective but increase the risk of severe bleeding because they target proteins that are essential for normal coagulation (hemostasis). Drugs with better safety profiles are required for prevention and treatment of thromboembolic disease. Coagulation factor XIa has emerged as a novel target for safer anticoagulant therapy because of its role in thrombosis and its relatively small contribution to hemostasis.

引用

页码：1454 / 1458

页数：5

共 41 条

[1]

Sulfated Pentagalloylglucoside Is a Potent, Allosteric, and Selective Inhibitor of Factor XIa [J].

Al-Horani, Rami A. ;

Ponnusamy, Pooja ;

Mehta, Akul Y. ;

Gailani, David ;

Desai, Umesh R. .

JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (03) :867-878

[2]

Tissue factor pathway inhibitor: structure-function [J].

Broze, George J., Jr. ;

Girard, Thomas J. .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2012, 17 :262-280

[3]

Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa [J].

Buchanan, Malcolm S. ;

Carroll, Anthony R. ;

Wessling, Deborah ;

Jobling, Michael ;

Avery, Vicky M. ;

Davis, Rohan A. ;

Feng, Yunjiang ;

Xue, Yafeng ;

Oster, Linda ;

Fex, Tomas ;

Deinum, Johanna ;

Hooper, John N. A. ;

Quinn, Ronald J. .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (12) :3583-3587

[4]

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo [J].

Cheng, Qiufang ;

Tucker, Erik I. ;

Pine, Meghann S. ;

Sisler, India ;

Matafonov, Anton ;

Sun, Mao-fu ;

White-Adams, Tara C. ;

Smith, Stephanie A. ;

Hanson, Stephen R. ;

McCarty, Owen J. T. ;

Renne, Thomas ;

Gruber, Andras ;

Gailani, David .

BLOOD, 2010, 116 (19) :3981-3989

[5]

Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates [J].

Crosby, Jeffrey R. ;

Marzec, Ulla ;

Revenko, Alexey S. ;

Zhao, Chenguang ;

Gao, Dacao ;

Matafonov, Anton ;

Gailani, David ;

MacLeod, A. Robert ;

Tucker, Erik I. ;

Gruber, Andras ;

Hanson, Stephen R. ;

Monia, Brett P. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (07) :1670-1678

[6]

Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an α-ketothiazole arginine [J].

Deng, HF ;

Bannister, TD ;

Jin, L ;

Babine, RE ;

Quinn, J ;

Nagafuji, P ;

Celatka, CA ;

Lin, J ;

Lazarova, TI ;

Rynkiewicz, MJ ;

Bibbins, F ;

Pandey, P ;

Gorga, J ;

Meyers, HV ;

Abdel-Meguid, SS ;

Strickler, JE .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (11) :3049-3054

[7]

Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: opposite and synergistic effects of factors XI and YII [J].

Doggen, Carine J. M. ;

Rosendaal, Frits R. ;

Meijers, Joost C. M. .

BLOOD, 2006, 108 (13) :4045-4051

[8]

Congenital Factor XI Deficiency: An Update [J].

Duga, Stefano ;

Salomon, Ophira .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2013, 39 (06) :621-631

[9]

Structure and function of factor XI [J].

Emsley, Jonas ;

McEwan, Paul A. ;

Gailani, David .

BLOOD, 2010, 115 (13) :2569-2577

[10]

Gailani D., 2013, HEMATOLOGY BASIC PRI, P1939

← 1 2 3 4 5 →