Zippers make signals: NCAM-mediated molecular interactions and signal transduction

被引:169
作者
Walmod, PS [1 ]
Kolkova, K [1 ]
Berezin, V [1 ]
Bock, E [1 ]
机构
[1] Univ Copenhagen, Inst Mol Pathol, Prot Lab, Copenhagen, Denmark
关键词
ATP; binding; CD56; cell adhesion molecule; chondroitin sulfate proteoglycans; fibroblast growth factor; focal adhesion kinase; Fyn; glial cell-line-derived neurotrophic factor; heparan sulfate proteoglycans; HNK-1; immunoglobulin; interaction; ligand; mimetic; NCAM; neurite outgrowth; palmitoylation; peptide; phosphorylation; polysialic acid; protein kinase; protein structure; signal transduction; VASE;
D O I
10.1007/s11064-004-6875-z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The neural cell adhesion molecule, NCAM, is involved in multiple cis- and trans-homophilic interactions (NCAM binding to NCAM) thereby facilitating cell-cell adhesion through the formation of zipper-like NCAM-complexes. NCAM is also involved in heterophilic interactions with a number of proteins and extracellular matrix molecules. Some of these heterophilic interactions are mutually exclusive, and some interfere with or are dependent on homophilic NCAM interactions. Furthermore, both homo- and heterophilic interactions are modulated by posttranslational modi. cations of NCAM. Heterophilic NCAM-interactions initiate several intracellular signal transduction pathways ultimately leading to biological responses involving cellular differentiation, proliferation, migration and survival. Both homo- and heterophilic NCAM-interactions can be mimicked by synthetic peptides, which can induce NCAM-like signalling, and in vitro and in vivo studies suggest that such NCAM mimetics may be used for the treatment of neurodegenerative disorders.
引用
收藏
页码:2015 / 2035
页数:21
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