Lamivudine therapy for a hepatitis B surface antigen (HBsAg)-positive leukemia patient receiving myeloablative chemotherapy and autologous stem cell transplantation

被引：15

作者：

Uchida, N

Gondo, H

Himeji, D

Kaji, Y

Sata, M

Niho, Y

机构：

[1] Kyushu Univ, Fac Med, Dept Internal Med 1, Fukuoka 812, Japan

[2] Kurume Univ, Fac Med, Dept Internal Med 2, Fukuoka 812, Japan

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 11期

关键词：

lamivudine; hepatitis type B; stem cell transplantation;

D O I：

10.1038/sj.bmt.1702693

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Hepatitis B virus (HBV) can be a cause of fatal liver failure after chemotherapy for viral carrier patients and limits the indication of myeloablative therapy for them. We describe an HBsAg-positive leukemia patient who successfully underwent autologous PBSC transplant. After chemotherapeutic treatment his serum HBV DNA level rose in association with hepatitis. To prevent progression to fulminant hepatitis, we administered lamivudine, a viral reverse transcriptase inhibitor, during the transplantation procedure. The patient did not show any increase of HBV DNA or a worsening of his hepatitis. Thus, lamivudine may be a promising treatment for HBsAg-positive patients receiving myeloablative chemotherapy and autologous stem cell transplantation.

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收藏

页码：1243 / 1245

页数：3

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