A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma

被引：26

作者：

Chamberlain, Marc C. ^{[1
]}

Chalmers, Lisa ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2007年 / 82卷 / 02期

关键词：

elderly patients; glioblastoma; dose-dense temozolomide; deferred radiotherapy;

D O I：

10.1007/s11060-006-9269-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

There is no standard of care for elderly patients (age >= 70 years) with newly diagnosed glioblastoma (GBM). In 15 consecutive patients (median age 79 years) treated with temozolomide (TMZ) (42 days on; 14 days off), median survival was 6 months (range 4-14 months). This pilot study suggests that low dose daily TMZ may represent an alternative and equally effective treatment to more traditionally administered radiotherapy.

引用

页码：207 / 209

页数：3

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