Properties of various RHO1 mutant alleles of Cryptococcus neoformans

被引：16

作者：

Chang, YC ^{[1
]}

Penoyer, LA ^{[1
]}

机构：

[1] NIAID, Clin Invest Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 17期

关键词：

D O I：

10.1128/JB.182.17.4987-4991.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The RHO1 homologue of Cryptococcus neoformans complemented Saccharomyces cerevisiae rho1 mutations. The results of overexpression and site-specific mutagenesis of CnRHO1 in C. neoformans and S. cerevisiae indicated that although CnRHO1 could functionally substitute for the RHO1 gene of S. cerevisiae, mutants of cnrho1 manifested unique features in certain aspects.

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页码：4987 / 4991

页数：5

相关论文

共 40 条

[1] Rho1 GTPase activates the (1-3)beta-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis [J].

Arellano, M ;

Duran, A ;

Perez, P .

EMBO JOURNAL, 1996, 15 (17) :4584-4591

[2] INVITRO ANTIFUNGAL ACTIVITIES AND INVIVO EFFICACIES OF 1,3-BETA-D-GLUCAN SYNTHESIS INHIBITORS L-671,329, L-646,991, TETRAHYDROECHINOCANDIN-B, AND L-687,781, A PAPULACANDIN [J].

BARTIZAL, K ;

ABRUZZO, G ;

TRAINOR, C ;

KRUPA, D ;

NOLLSTADT, K ;

SCHMATZ, D ;

SCHWARTZ, R ;

HAMMOND, M ;

BALKOVEC, J ;

VANMIDDLESWORTH, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (08) :1648-1657

[3]

BOURNE HR, 1991, NATURE, V349, P117, DOI 10.1038/349117a0

[4] Cell wall and secreted proteins of Candida albicans:: Identification, function, and expression [J].

Chaffin, WL ;

López-Ribot, JL ;

Casanova, M ;

Gozalbo, D ;

Martinez, JP .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1998, 62 (01) :130-+

[5] Cryptococcus neoformans STE12α regulates virulence but is not essential for mating [J].

Chang, YC ;

Wickes, BL ;

Miller, GF ;

Penoyer, LA ;

Kwon-Chung, KJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (05) :871-881

[6] COMPLEMENTATION OF A CAPSULE-DEFICIENT MUTATION OF CRYPTOCOCCUS-NEOFORMANS RESTORES ITS VIRULENCE [J].

CHANG, YC ;

KWONCHUNG, KJ .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) :4912-4919

[7] MOLECULAR-BASIS OF CELL INTEGRITY AND MORPHOGENESIS IN SACCHAROMYCES-CEREVISIAE [J].

CID, VJ ;

DURAN, A ;

DELREY, F ;

SNYDER, MP ;

NOMBELA, C ;

SANCHEZ, M .

MICROBIOLOGICAL REVIEWS, 1995, 59 (03) :345-386

[8] ANTIBIOTICS THAT INHIBIT FUNGAL CELL-WALL DEVELOPMENT [J].

DEBONO, M ;

GORDEE, RS .

ANNUAL REVIEW OF MICROBIOLOGY, 1994, 48 :471-497

[9] THE SACCHAROMYCES-CEREVISIAE FKS1 (ETG1) GENE ENCODES AN INTEGRAL MEMBRANE-PROTEIN WHICH IS A SUBUNIT OF 1,3-BETA-D-GLUCAN SYNTHASE [J].

DOUGLAS, CM ;

FOOR, F ;

MARRINAN, JA ;

MORIN, N ;

NIELSEN, JB ;

DAHL, AM ;

MAZUR, P ;

BAGINSKY, W ;

LI, WL ;

ELSHERBEINI, M ;

CLEMAS, JA ;

MANDALA, SM ;

FROMMER, BR ;

KURTZ, MB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (26) :12907-12911

[10] Rho1p, a yeast protein at the interface between cell polarization and morphogenesis [J].

Drgonova, J ;

Drgon, T ;

Tanaka, K ;

Kollar, R ;

Chen, GC ;

Ford, RA ;

Chan, CSM ;

Takai, Y ;

Cabib, E .

SCIENCE, 1996, 272 (5259) :277-279

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