Structural and mechanistic insights into hepatitis C viral translation initiation

被引：172

作者：

Fraser, Christopher S.

Doudna, Jennifer A. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[3] Lawrence Berkeley Lab, Phys Biosci Div, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrmicro1558

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis C virus uses an internal ribosome entry site (IRES) to control viral protein synthesis by directly recruiting ribosomes to the translation-start site in the viral mRNA. Structural insights coupled with biochemical studies have revealed that the IRES substitutes for the activities of translation-initiation factors by binding and inducing conformational changes in the 40S ribosomal subunit. Direct interactions of the IRES with initiation factor elF3 are also crucial for efficient translation initiation, providing clues to the role of elF3 in protein synthesis.

引用

页码：29 / 38

页数：10

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