Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host

被引：103

作者：

Speziale, Pietro ^{[1
]}

Pietrocola, Giampiero ^{[1
]}

Rindi, Simonetta ^{[1
]}

Provenzano, Maria ^{[1
]}

Provenza, Giulio ^{[1
]}

Di Poto, Antonella ^{[1
]}

Visai, Livia ^{[1
,2
]}

Arciola, Carla Renata ^{[3
,4
]}

机构：

[1] Dept Biochem, I-27100 Pavia, Italy

[2] CIT, Ctr Tissue Engn, I-27100 Pavia, Italy

[3] Rizzoli Orthopaed Inst, Res Unit Implant Infect, I-40136 Bologna, Italy

[4] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

来源：

FUTURE MICROBIOLOGY | 2009年 / 4卷 / 10期

关键词：

adhesion; extracellular matrix; MSCRAMM; Staphylococcus aureus; vaccine; FIBRONECTIN-BINDING PROTEIN; CLUMPING FACTOR-A; FACTOR-B CLFB; FIBRINOGEN-BINDING; COLLAGEN ADHESIN; IGG-BINDING; VIRULENCE FACTOR; PLATELET-AGGREGATION; MEDIATES ADHESION; CRYSTAL-STRUCTURE;

D O I：

10.2217/FMB.09.102

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections, S, aureus can initiate host infection by adhering to components of the extracellular matrix, Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.

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页码：1337 / 1352

页数：16

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